A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
نویسندگان
چکیده
منابع مشابه
A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2015
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc03002a